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KMID : 0613820130230091104
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Journal of Life Science
2013 Volume.23 No. 9 p.1104 ~ p.1108
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Regulation of Unfolded Protein Response by Ethylene Glycol in Rat
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Lee Eun-Ryeong
Kwon Ki-sang
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Abstract
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Ethylene glycol (EG) is the most commonly used for automotive antifreeze, and it's easily misuseful for human. EG poisoning occurs in suicide attempts and infrequently, either intentionally through misuse or accidentally because of sweet taste. Though EG itself is mild toxic to the human body, it becomes higher toxic organic acids by in vivo broken down that are responsible for extensive cellular damage in various tissues caused principally by the metabolites. It is already well known that various cellular stresses induce gene expression of endoplasmic reticulum (ER) chaperones and ER stress sensors. This study demonstrated that regulation of gene expression of ER chaperones and ER stress sensors was induced by EG in rat tissues, and in tissues histological changes are also detected by both staining H&E and immunofluorescent.
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KEYWORD
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Ethylene glycol (EG), endoplasmic reticulum (ER) chaperones, ER stress sensors
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